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desvenlafaxine will raise the amount or effect of codeine by impacting hepatic enzyme CYP2D6 metabolism. Use Warning/Observe. Desvenlafaxine inhibits CYP2D6; with larger desvenlafaxine doses (ie, 400 mg) minimize the CYP2D6 substrate dose by up to 50%; no dosage adjustment essential with desvenlafaxine doses seven consecutive days quickly ahead of